Oklahoma improved to 14-1 with its ninth straight win. Meanwhile, MSU, playing its first road game of the season, fell to 9-4.
The Sooners removed all doubt from this contest by scoring 11 runs over the first three innings, including a six-run bottom of the first inning. OU actually erased a 1-0 deficit with that big outburst.
The Bulldogs scored again in the second inning when an unearned run cut the deficit to 6-2. However, OU chased MSU starter Nick Routt with two runs in the second inning. Routt (0-1) lasted only 1.1 innings, allowing seven hits and eight runs (all earned), with a walk and a strikeout.
The Sooners ran the lead to 11-2 on a bases-clearing double by first baseman Cameron Seitzer. Seitzer had three of the Sooners' 19 hits, while driving in five runs. It was the second bases-clearing double for OU, as Ross Hubbard accomplished the same in the first inning.
Drew Harrison hit the only home run in the contest - a two-run shot - to cap the Oklahoma scoring in the eighth inning.
The Bulldogs finished with eight hits. Powers had the only multi-hit game for the Maroon and White. Chris Ellison joined Seitzer in the three-hit club for the Sooners. Garrett Buechele, Caleb Bushyhead, Danny Black and Hubbard each had multi-hit games.
Starting pitcher Zach Neal (2-0) worked 6.1 innings to pick up the win. Neal allowed six hits and four runs (three earned), with eight strikeouts and one walk. A trio of Sooners followed, with Jarrett Seimer completing the contest.